X0508 4 2023-10-13 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001754648 MCKENZIE DIANA C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 0 Deferred Stock Units 2023-10-13 4 A 0 89.532 369.98 A Common Stock 89.532 4745.98 D Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. /s/ Christiana Stevenson, Attorney-in-Fact 2023-10-17