X0407 4 2023-05-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001754648 MCKENZIE DIANA C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 0 Common Stock 2023-05-01 4 D 0 1449 D 1435 D Common Stock 2023-05-01 4 A 0 1168 0.00 A 2603 D Common Stock 207 I Held in Trust Deferred Stock Units 2023-05-01 4 A 0 1449 A Common Stock 1449 4566.521 D Upon the vesting of restricted stock units granted to Ms. McKenzie on May 1, 2022, Ms. McKenzie deferred the receipt of 1,449 shares of common stock and received instead 1,449 deferred stock units pursuant to our deferred compensation plan. As a result, Ms. McKenzie is reporting the disposition of 1,449 shares of common stock in exchange for an equal number of deferred stock units. Restricted stock unit award that vests, subject to certain limited exceptions, on the first anniversary of the grant date. Each deferred stock unit represents one share of common stock and is paid out in common stock upon the earliest to occur of (i) termination of Ms. McKenzie's service on our board of directors, (ii) a change of control of our company and (iii) Ms. McKenzie's disability or death. /s/ Christiana Stevenson, Attorney-in-Fact 2023-05-03