X0407 4 2023-04-04 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001829069 Sanna Bastiano C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Cell & Genetic Therapies 1 Common Stock 2023-04-04 4 S 0 211 314.22 D 47591 D Common Stock 2023-04-04 4 S 0 94 315.66 D 47497 D Common Stock 2023-04-04 4 S 0 90 316.76 D 47407 D Common Stock 2023-04-04 4 S 0 96 317.65 D 47311 D Common Stock 2023-04-04 4 S 0 31 318.68 D 47280 D Transaction made pursuant to Mr. Sanna's company approved trading plan under Rule 10b5-1, which was entered into on 08/10/2022. Mr. Sanna undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $314.22 (range $313.72 to $314.70). Open market sales reported on this line occurred at a weighted average price of $315.66 (range $315.08 to $315.96). Open market sales reported on this line occurred at a weighted average price of $316.76 (range $316.41 to $317.20). Open market sales reported on this line occurred at a weighted average price of $317.65 (range $317.49 to $317.74). /s/ Christiana Stevenson, Attorney-in-Fact 2023-04-06