X0306 4 2023-02-24 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001789815 Tatsis Ourania C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Reg. & Quality Off. Common Stock 2023-02-24 4 F 0 3308 289.12 D 57159 D Common Stock 2023-02-27 4 S 0 283 287.20 D 56876 D Common Stock 2023-02-27 4 S 0 51 288.33 D 56825 D Common Stock 2023-02-27 4 S 0 20 289.29 D 56805 D Transaction made pursuant to Ms. Tatsis' company approved trading plan under Rule 10b5-1. Ms. Tatsis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $287.20 (range $286.71 to $287.60). Open market sales reported on this line occurred at a weighted average price of $288.33 (range $287.82 to $288.74). Open market sales reported on this line occurred at a weighted average price of $289.29 (range $289.17 to $289.40). /s/ Joy Liu, Attorney-in-Fact 2023-02-28