X0306 4 2023-02-10 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001557290 Arbuckle Stuart A C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, COO Common Stock 2023-02-10 4 F 0 3372 294.33 D 92880 D Common Stock 2023-02-13 4 F 0 5990 298.26 D 86890 D Common Stock 2023-02-13 4 S 0 245 296.44 D 86645 D Common Stock 2023-02-13 4 S 0 2028 298.42 D 84617 D Common Stock 2023-02-13 4 S 0 1779 299.26 D 82838 D Common Stock 2023-02-13 4 S 0 835 300.13 D 82003 D Common Stock 140 I 401(k) Transaction made pursuant to Mr. Arbuckle's company approved trading plan under Rule 10b5-1. Mr. Arbuckle undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $296.44 (range $295.84 to $296.57). Open market sales reported on this line occurred at a weighted average price of $298.42 (range $297.85 to $298.80). Open market sales reported on this line occurred at a weighted average price of $299.26 (range $298.86 to $299.81). Open market sales reported on this line occurred at a weighted average price of $300.13 (range $299.93 to $300.53). /s/ Christiana Stevenson, Attorney-in-Fact 2023-02-14