X0306 4 2023-02-10 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001550395 ALTSHULER DAVID C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Global Research and CSO Common Stock 2023-02-10 4 F 0 3461 294.33 D 65184 D Common Stock 2023-02-13 4 F 0 5990 298.26 D 59194 D Common Stock 2023-02-13 4 S 0 245 296.44 D 58949 D Common Stock 2023-02-13 4 S 0 2160 298.47 D 56789 D Common Stock 2023-02-13 4 S 0 1893 299.36 D 54896 D Common Stock 2023-02-13 4 S 0 500 300.23 D 54396 D Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1. Dr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $296.44 (range $295.84 to $296.57). Open market sales reported on this line occurred at a weighted average price of $298.47 (range $297.85 to $298.82). Open market sales reported on this line occurred at a weighted average price of $299.36 (range $298.86 to $299.83). Open market sales reported on this line occurred at a weighted average price of $300.23 (range $299.96 to $300.63). /s/ Christiana Stevenson, Attorney-in-Fact 2023-02-14