X0306 4 2023-02-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001789815 Tatsis Ourania C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Reg. & Quality Off. Common Stock 2023-02-01 4 A 0 6194 0.00 A 52284 D Common Stock 2023-02-01 4 A 0 10262 0.00 A 62546 D Common Stock 2023-02-01 4 A 0 7866 0.00 A 70412 D Represents earned performance shares with respect to a performance stock unit award granted on 02/05/2020 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/01/2023 and the shares will vest on 02/13/2023. Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/01/2023 and the shares will vest in installments beginning on 02/24/2023. Restricted stock unit award that vests in installments beginning on 02/10/2024. /s/ Christiana Stevenson, Attorney-in-Fact 2023-02-03