X0306 4 2023-02-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 1 0 0 Executive Chairman Common Stock 2023-02-01 4 A 0 31462 0.00 A 33885 D Common Stock 2023-02-01 4 A 0 34890 0.00 A 68775 D Common Stock 2023-02-01 4 A 0 10226 0.00 A 79001 D Common Stock 2023-02-02 4 F 0 3578 317.83 D 75423 D Common Stock 440 I 401(k) Represents earned performance shares with respect to a performance stock unit award granted on 02/05/2020 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/01/2023 and the shares will vest on 02/13/2023. Represents earned performance shares with respect to a performance stock unit award granted on 02/01/2022 that contained performance-vesting requirements. The issuer's management development and compensation committee certified as to the level of performance-goal attainment on 02/01/2023 and the shares will vest on 02/24/2023. Restricted stock unit award that fully vested upon grant. /s/ Christiana Stevenson, Attorney-in-Fact 2023-02-03