X0306 4 2023-01-31 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197036 SACHS BRUCE I C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVE BOSTON MA 02210 1 0 0 0 Common Stock 2023-01-31 4 M 0 1200 72.14 A 42410 D Common Stock 2023-01-31 4 S 0 1200 325.01 D 41210 D Stock Option (Right to Buy) 72.14 2023-01-31 4 M 0 1200 0.00 D 2024-05-31 Common Stock 1200 21300 D Transaction made pursuant to Mr. Sachs' company approved trading plan under Rule 10b5-1. Mr. Sachs undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $325.01 (range $325.00 to $325.01). Fully vested. /s/ Christiana Stevenson, Attorney-in-Fact 2023-02-02