X0306 4 2023-01-30 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001204424 CARNEY LLOYD C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2023-01-30 4 S 0 1376 320.08 D 5474 D Common Stock 2023-01-30 4 S 0 1000 320.70 D 4474 D Common Stock 2023-01-30 4 S 0 324 321.84 D 4150 D Transaction made pursuant to Mr. Carney's company approved trading plan under Rule 10b5-1. Mr. Carney undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $320.08 (range $319.40 to $320.38). Open market sales reported on this line occurred at a weighted average price of $320.70 (range $320.43 to $321.31). Open market sales reported on this line occurred at a weighted average price of $321.84 (range $321.54 to $322.23). /s/ Christiana Stevenson, Attorney-in-Fact 2023-01-31