X0306 4 2021-11-15 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001406338 Sachdev Amit C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Patient Officer Common Stock 2021-11-15 4 S 0 21 186.78 D 31958 D Common Stock 2021-11-15 4 S 0 30 187.48 D 31928 D Common Stock 882 I 401(k) Common Stock 15573 I Held in Trust Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $186.78 (range $186.22 to $187.19). Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $187.48 (range $187.24 to $187.85). /s/ Sabrina Yohai, Attorney-in-Fact 2021-11-16