X0306 4 2021-05-17 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001406338 Sachdev Amit C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Patient Officer Common Stock 2021-05-17 4 S 0 8 215.59 D 40170 D Common Stock 2021-05-17 4 S 0 32 216.40 D 40138 D Common Stock 2021-05-17 4 S 0 5 217.27 D 40133 D Common Stock 882 I 401(k) Common Stock 7368 I Held in Trust Transaction made pursuant to Mr. Sachdev's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $215.59 (range $214.94 to $215.93). Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $216.40 (range $215.95 to $216.91). Open market sales reported on this line occurred at a weighted average price of $217.27 (range $217.05 to $217.46). /s/ Sabrina Yohai, Attorney-in-Fact 2021-05-19