X0306 4 2021-05-17 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001550395 ALTSHULER DAVID C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Global Research and CSO Common Stock 2021-05-17 4 S 0 8 215.31 D 33660 D Common Stock 2021-05-17 4 S 0 56 216.31 D 33604 D Common Stock 2021-05-17 4 S 0 15 217.13 D 33589 D Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $215.31 (range $214.83 to $215.77). Dr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $216.31 (range $215.83 to $216.80). Open market sales reported on this line occurred at a weighted average price of $217.13 (range $216.86 to $217.50). /s/ Sabrina Yohai, Attorney-in-Fact 2021-05-19