X0306 4 2021-02-17 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001406338 Sachdev Amit C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Patient Officer Common Stock 2021-02-17 4 F 0 7613 211.75 D 55929 D Common Stock 2021-02-18 4 S 0 1164 210.00 D 54765 D Common Stock 2021-02-18 4 S 0 1500 211.36 D 53265 D Common Stock 2021-02-18 4 S 0 5800 212.15 D 47465 D Common Stock 2021-02-18 4 S 0 800 213.02 D 46665 D Common Stock 882 I 401(k) Common Stock 7368 I Held in trust Transaction made pursuant to Mr. Sachdev's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $210.00 (range $209.61 to $210.34). Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $211.36 (range $210.74 to $211.64). Open market sales reported on this line occurred at a weighted average price of $212.15 (range $211.74 to $212.70). Open market sales reported on this line occurred at a weighted average price of $213.02 (range $212.74 to $213.33). /s/ Sabrina Yohai, Attorney-in-Fact 2021-02-19