X0306 4 2021-02-17 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Adm, Leg & BD Off Common Stock 2021-02-17 4 F 0 6240 211.75 D 44106 D Common Stock 2021-02-18 4 S 0 1007 210.08 D 43099 D Common Stock 2021-02-18 4 S 0 4666 211.83 D 38433 D Common Stock 2021-02-18 4 S 0 1952 212.56 D 36481 D Common Stock 2021-02-18 4 S 0 200 213.45 D 36281 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $210.08 (range $209.60 to $210.54). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $211.83 (range $211.25 to $212.24). Open market sales reported on this line occurred at a weighted average price of $212.56 (range $212.25 to $212.95). Open market sales reported on this line occurred at a weighted average price of $213.45 (range $213.30 to $213.68). /s/ Sabrina Yohai, Attorney-in-Fact 2021-02-19