X0306 4 2020-05-15 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001550395 ALTSHULER DAVID C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Global Research and CSO Common Stock 2020-05-15 4 S 0 2 274.98 D 28982 D Common Stock 2020-05-15 4 S 0 4 276.44 D 28978 D Common Stock 2020-05-15 4 S 0 5 279.48 D 28973 D Common Stock 2020-05-15 4 S 0 9 280.47 D 28964 D Common Stock 2020-05-15 4 S 0 4 281.55 D 28960 D Common Stock 2020-05-15 4 S 0 6 282.77 D 28954 D Common Stock 2020-05-15 4 S 0 3 283.74 D 28951 D Common Stock 2020-05-15 4 S 0 5 284.98 D 28946 D Common Stock 2020-05-15 4 S 0 10 286.12 D 28936 D Common Stock 2020-05-15 4 S 0 15 287.19 D 28921 D Common Stock 2020-05-15 4 S 0 19 288.05 D 28902 D Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $274.98 (range $274.67 to $275.28). Dr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $276.44 (range $276.23 to $276.75). Open market sales reported on this line occurred at a weighted average price of $279.48 (range $278.84 to $279.82). Open market sales reported on this line occurred at a weighted average price of $280.47 (range $280.21 to $280.68). Open market sales reported on this line occurred at a weighted average price of $281.55 (range $281.24 to $282.20). Open market sales reported on this line occurred at a weighted average price of $282.77 (range $282.36 to $283.28). Open market sales reported on this line occurred at a weighted average price of $283.74 (range $283.44 to $284.05). Open market sales reported on this line occurred at a weighted average price of $284.98 (range $284.56 to $285.43). Open market sales reported on this line occurred at a weighted average price of $286.12 (range $285.60 to $286.43). Open market sales reported on this line occurred at a weighted average price of $287.19 (range $286.61 to $287.60). Open market sales reported on this line occurred at a weighted average price of $288.05 (range $287.70 to $288.47). /s/ Sabrina Yohai, Attorney-in-Fact 2020-05-19