X0306 4 2020-05-12 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 1 0 0 Executive Chairman Common Stock 2020-05-12 4 M 0 24215 187.53 A 65036 D Common Stock 2020-05-12 4 M 0 35499 96.87 A 100535 D Common Stock 2020-05-12 4 M 0 4470 91.05 A 105005 D Common Stock 2020-05-12 4 M 0 24348 155.57 A 129353 D Common Stock 2020-05-12 4 S 0 9015 277.14 D 120338 D Common Stock 2020-05-12 4 S 0 4428 277.94 D 115910 D Common Stock 2020-05-12 4 S 0 1940 278.96 D 113970 D Common Stock 2020-05-12 4 S 0 6498 280.76 D 107472 D Common Stock 2020-05-12 4 S 0 9398 281.83 D 98074 D Common Stock 2020-05-12 4 S 0 9780 282.66 D 88294 D Common Stock 2020-05-12 4 S 0 9219 283.86 D 79075 D Common Stock 2020-05-12 4 S 0 10179 285.06 D 68896 D Common Stock 2020-05-12 4 S 0 8391 285.68 D 60505 D Common Stock 2020-05-12 4 S 0 15792 286.70 D 44713 D Common Stock 2020-05-12 4 S 0 9630 287.81 D 35083 D Common Stock 2020-05-12 4 S 0 100 288.42 D 34983 D Common Stock 440 I 401(k) Stock Option (Right to Buy) 187.53 2020-05-12 4 M 0 24215 0.00 D 2029-02-05 Common Stock 24215 0 D Stock Option (Right to Buy) 96.87 2020-05-12 4 M 0 35499 0.00 D 2024-07-14 Common Stock 35499 0 D Stock Option (Right to Buy) 91.05 2020-05-12 4 M 0 4470 0.00 D 2026-02-01 Common Stock 4470 93866 D Stock Option (Right to Buy) 155.57 2020-05-12 4 M 0 24348 0.00 D 2028-02-05 Common Stock 24348 0 D Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $277.14 (range $276.63 to $277.61). Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $277.94 (range $277.63 to $278.41). Open market sales reported on this line occurred at a weighted average price of $278.96 (range $278.71 to $279.10). Open market sales reported on this line occurred at a weighted average price of $280.76 (range $280.17 to $281.13). Open market sales reported on this line occurred at a weighted average price of $281.83 (range $281.29 to $282.24). Open market sales reported on this line occurred at a weighted average price of $282.66 (range $282.33 to $283.28). Open market sales reported on this line occurred at a weighted average price of $283.86 (range $283.35 to $284.30). Open market sales reported on this line occurred at a weighted average price of $285.06 (range $284.36 to $285.35). Open market sales reported on this line occurred at a weighted average price of $285.68 (range $285.36 to $286.35). Open market sales reported on this line occurred at a weighted average price of $286.70 (range $286.37 to $287.31). Open market sales reported on this line occurred at a weighted average price of $287.81 (range $287.37 to $288.27). Fully vested. /s/ Sabrina Yohai, Attorney-in-Fact 2020-05-14