X0306 4 2020-05-05 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 1 0 0 Executive Chairman Common Stock 2020-05-05 4 M 0 24216 187.53 A 76707 D Common Stock 2020-05-05 4 M 0 35502 96.87 A 112209 D Common Stock 2020-05-05 4 M 0 4470 91.05 A 116679 D Common Stock 2020-05-05 4 M 0 24349 155.57 A 141028 D Common Stock 2020-05-05 4 S 0 4220 265.57 D 136808 D Common Stock 2020-05-05 4 S 0 4921 266.66 D 131887 D Common Stock 2020-05-05 4 S 0 10878 267.62 D 121009 D Common Stock 2020-05-05 4 S 0 22613 268.86 D 98396 D Common Stock 2020-05-05 4 S 0 15681 269.56 D 82715 D Common Stock 2020-05-05 4 S 0 6003 270.86 D 76712 D Common Stock 2020-05-05 4 S 0 11832 272.12 D 64880 D Common Stock 2020-05-05 4 S 0 12849 272.97 D 52031 D Common Stock 2020-05-05 4 S 0 5375 273.70 D 46656 D Common Stock 440 I 401(k) Stock Option (Right to Buy) 187.53 2020-05-05 4 M 0 24216 0.00 D 2029-02-25 Common Stock 24216 48431 D Stock Option (Right to Buy) 96.87 2020-05-05 4 M 0 35502 0.00 D 2024-07-14 Common Stock 35502 70998 D Stock Option (Right to Buy) 91.05 2020-05-05 4 M 0 4470 0.00 D 2026-02-01 Common Stock 4470 102806 D Stock Option (Right to Buy) 155.57 2020-05-05 4 M 0 24349 0.00 D 2028-02-05 Common Stock 24349 48697 D Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $265.57 (range $265.16 to $266.10). Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $266.66 (range $266.16 to $267.14). Open market sales reported on this line occurred at a weighted average price of $267.62 (range $267.16 to $268.14). Open market sales reported on this line occurred at a weighted average price of $268.86 (range $268.23 to $269.22). Open market sales reported on this line occurred at a weighted average price of $269.56 (range $269.24 to $270.09). Open market sales reported on this line occurred at a weighted average price of $270.86 (range $270.26 to $271.23). Open market sales reported on this line occurred at a weighted average price of $272.12 (range $271.42 to $272.41). Open market sales reported on this line occurred at a weighted average price of $272.97 (range $272.42 to $273.41). Open market sales reported on this line occurred at a weighted average price of $273.70 (range $273.42 to $274.06). Fully vested. /s/ Sabrina Yohai, Attorney-in-Fact 2020-05-07