X0306 4 2020-04-29 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Chief Adm, Leg & BD Off Common Stock 2020-04-29 4 M 0 2125 90.29 A 28963 D Common Stock 2020-04-29 4 S 0 145 251.38 D 28818 D Common Stock 2020-04-29 4 S 0 300 252.70 D 28518 D Common Stock 2020-04-29 4 S 0 400 254.20 D 28118 D Common Stock 2020-04-29 4 S 0 680 255.44 D 27438 D Common Stock 2020-04-29 4 S 0 500 256.63 D 26938 D Common Stock 2020-04-29 4 S 0 100 258.15 D 26838 D Stock Option (Right to Buy) 90.29 2020-04-29 4 M 0 2125 0.00 D 2026-07-11 Common Stock 2125 2125 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $251.38 (range $251.37 to $251.38). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $252.70 (range $252.48 to $252.96). Open market sales reported on this line occurred at a weighted average price of $254.20 (range $253.60 to $254.55). Open market sales reported on this line occurred at a weighted average price of $255.44 (range $255.03 to $255.97). Open market sales reported on this line occurred at a weighted average price of $256.63 (range $256.35 to $256.96). The option vests in 16 quarterly installments from 07/12/2016. /s/ Omar White, Attorney-in-Fact 2020-05-01