X0306 4 2020-02-10 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, CL&AO Common Stock 2020-02-10 4 F 0 13458 240.95 D 54788 D Common Stock 2020-02-11 4 S 0 922 243.42 D 53866 D Common Stock 2020-02-11 4 S 0 2102 244.67 D 51764 D Common Stock 2020-02-11 4 S 0 6232 245.62 D 45532 D Common Stock 2020-02-11 4 S 0 3783 246.52 D 41749 D Common Stock 2020-02-11 4 S 0 2499 247.62 D 39250 D Common Stock 2020-02-11 4 S 0 1344 248.52 D 37906 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $243.42 (range $242.88 to $243.81). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $244.67 (range $243.94 to $244.93). Open market sales reported on this line occurred at a weighted average price of $245.62 (range $245.12 to $246.11). Open market sales reported on this line occurred at a weighted average price of $246.52 (range $246.14 to $247.11). Open market sales reported on this line occurred at a weighted average price of $247.62 (range $247.14 to $248.08). Open market sales reported on this line occurred at a weighted average price of $248.52 (range $248.23 to $248.93). /s/ Omar White, Attorney-in-Fact 2020-02-12