X0306 4 2020-02-10 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001550395 ALTSHULER DAVID C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, Global Research and CSO Common Stock 2020-02-10 4 F 0 13308 240.95 D 57002 D Common Stock 2020-02-11 4 S 0 1000 243.36 D 56002 D Common Stock 2020-02-11 4 S 0 3400 244.89 D 52602 D Common Stock 2020-02-11 4 S 0 5725 245.81 D 46877 D Common Stock 2020-02-11 4 S 0 3472 246.73 D 43405 D Common Stock 2020-02-11 4 S 0 2235 247.73 D 41170 D Common Stock 2020-02-11 4 S 0 1200 248.50 D 39970 D Transaction made pursuant to Dr. Altshuler's company approved trading plan under Rule 10b5-1. Dr. Altshuler undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $243.36 (range $242.88 to $243.79). Open market sales reported on this line occurred at a weighted average price of $244.89 (range $244.28 to $245.25). Open market sales reported on this line occurred at a weighted average price of $245.81 (range $245.29 to $246.24). Open market sales reported on this line occurred at a weighted average price of $246.73 (range $246.29 to $247.26). Open market sales reported on this line occurred at a weighted average price of $247.73 (range $247.36 to $248.28). Open market sales reported on this line occurred at a weighted average price of $248.50 (range $248.37 to $248.82). /s/ Omar White, Attorney-in-Fact 2020-02-12