X0306 4 2020-01-06 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, CL&AO Common Stock 2020-01-06 4 M 0 4250 122.45 A 39253 D Common Stock 2020-01-06 4 S 0 400 218.93 D 38853 D Common Stock 2020-01-06 4 S 0 461 220.69 D 38392 D Common Stock 2020-01-06 4 S 0 1599 221.49 D 36793 D Common Stock 2020-01-06 4 S 0 398 222.67 D 36395 D Common Stock 2020-01-06 4 S 0 1063 223.60 D 35332 D Common Stock 2020-01-06 4 S 0 329 224.11 D 35003 D Stock Option (Right to Buy) 122.45 2020-01-06 4 M 0 4250 0.00 D 2026-01-03 Common Stock 4250 0 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $218.93 (range $218.40 to $219.37). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $220.69 (range $220.32 to $220.99). Open market sales reported on this line occurred at a weighted average price of $221.49 (range $221.00 to $221.82). Open market sales reported on this line occurred at a weighted average price of $222.67 (range $222.14 to $222.99). Open market sales reported on this line occurred at a weighted average price of $223.60 (range $223.19 to $223.99). Open market sales reported on this line occurred at a weighted average price of $224.11 (range $224.02 to $224.27). Fully vested. /s/ Omar White, Attorney-in-Fact 2020-01-08