X0306 4 2019-05-03 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, CL&AO Common Stock 2019-05-03 4 M 0 2329 86.52 A 37332 D Comon Stock 2019-05-03 4 S 0 500 170.33 D 36832 D Common Stock 2019-05-03 4 S 0 500 171.71 D 36332 D Common Stock 2019-05-30 4 S 0 707 173.00 D 35625 D Common Stock 2019-05-03 4 S 0 622 173.72 D 35003 D Stock Option (Right to Buy) 86.52 2019-05-03 4 M 0 2329 0.00 A 2027-02-02 Common Stock 2329 16310 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $170.33 (range $169.96 to $170.63). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $171.71 (range $171.35 to $172.16). Open market sales reported on this line occurred at a weighted average price of $173.00 (range $172.54 to $173.39). Open market sales reported on this line occurred at a weighted average price of $173.72 (range $173.55 to $173.91). The option vests in 16 quarterly installments from 02/03/2017. /s/ Omar White, Attorney-in-Fact 2019-05-06