X0306 4 2019-04-16 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001661567 Parini Michael 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, CL&AO Common Stock 2019-04-16 4 M 0 4250 122.45 A 39253 D Common Stock 2019-04-16 4 S 0 870 179.91 D 38383 D Common Stock 2019-04-16 4 S 0 815 181.31 D 37568 D Common Stock 2019-04-16 4 S 0 1605 182.19 D 35963 D Common Stock 2019-04-16 4 S 0 300 183.26 D 35663 D Common Stock 2019-04-16 4 S 0 660 184.44 D 35003 D Common Stock 2019-04-16 4 M 0 2125 90.29 A 37128 D Common Stock 2019-04-16 4 S 0 425 179.84 D 36703 D Common Stock 2019-04-16 4 S 0 600 181.49 D 36103 D Common Stock 2019-04-16 4 S 0 600 182.24 D 35503 D Common Stock 2019-04-16 4 S 0 100 183.15 D 35403 D Common Stock 2019-04-16 4 S 0 400 184.42 D 35003 D Stock Option (Right to Buy) 122.45 2019-04-16 4 M 0 4250 0.00 D 2026-01-03 Common Stock 4250 12750 D Stock Option (Right to Buy) 90.29 2019-04-16 4 M 0 2125 0.00 D 2026-07-11 Common Stock 2125 10625 D Transaction made pursuant to Mr. Parini's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $179.91 (range $179.68 to $180.55). Mr. Parini undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $181.31 (range $180.82 to $181.67). Open market sales reported on this line occurred at a weighted average price of $182.19 (range $181.84 to $182.67). Open market sales reported on this line occurred at a weighted average price of $183.26 (range $183.13 to $183.48). Open market sales reported on this line occurred at a weighted average price of $184.44 (range $184.18 to $184.71). Open market sales reported on this line occurred at a weighted average price of $179.84 (range $179.63 to $180.30). Open market sales reported on this line occurred at a weighted average price of $181.49 (range $180.97 to $181.95). Open market sales reported on this line occurred at a weighted average price of $182.24 (range $182.06 to $182.53). Open market sales reported on this line occurred at a weighted average price of $184.42 (range $184.18 to $184.71). The option vests in 16 quarterly installments from 1/4/2016. The option vests in 16 quarterly installments from 7/12/2016. /s/ Omar White, Attorney-in-Fact 2019-04-18