X0306 4 2018-02-05 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001406338 Sachdev Amit C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 EVP, CRO Common Stock 2018-02-05 4 M 0 1942 86.52 A 41105 D Common Stock 2018-02-05 4 M 0 2578 77.31 A 43683 D Common Stock 2018-02-05 4 S 0 378 158.55 D 43305 D Common Stock 2018-02-05 4 S 0 700 159.93 D 42605 D Common Stock 2018-02-05 4 S 0 300 160.97 D 42305 D Common Stock 2018-02-05 4 S 0 300 161.93 D 42005 D Common Stock 2018-02-05 4 S 0 600 163.79 D 41405 D Common Stock 2018-02-05 4 S 0 2242 164.93 D 39163 D Common Stock 882 I 401(k) Common Stock 12215 I Held in Trust Stock Option (Right to Buy) 86.52 2018-02-05 4 M 0 1942 0.00 D 2027-02-02 Common Stock 1942 23299 D Stock Option (Right to Buy) 77.31 2018-02-05 4 M 0 2578 0.00 D 2024-02-04 Common Stock 2578 0 D Transaction made pursuant to Mr. Sachdev's company-approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $158.55 (range $158.24 to $159.09). Mr. Sachdev undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $159.93 (range $159.46 to $160.47). Open market sales reported on this line occurred at a weighted average price of $160.97 (range $160.51 to $161.26). Open market sales reported on this line occurred at a weighted average price of $161.93 (range $161.70 to $162.39). Open market sales reported on this line occurred at a weighted average price of $163.79 (range $163.23 to $164.22). Open market sales reported on this line occurred at a weighted average price of $164.93 (range $164.31 to $165.06). The option vests in 16 quarterly installments from 2/3/2017. Fully vested. /s/ Omar White, Attorney-in-Fact 2018-02-07