X0306 4 2015-11-18 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197023 BOGER JOSHUA S C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2015-11-18 4 M 0 10400 35.64 A 355684 D Common Stock 2015-11-18 4 S 0 2800 128.96 D 352884 D Common Stock 2015-11-18 4 S 0 800 130.25 D 352084 D Common Stock 2015-11-18 4 S 0 3100 131.55 D 348984 D Common Stock 2015-11-18 4 S 0 3300 132.44 D 345684 D Common Stock 2015-11-18 4 S 0 400 133.03 D 345284 D Common Stock 13286 I 401(k) Common Stock 122700 I Common Stock held in trust Stock Option (right to buy) 35.64 2015-11-18 4 M 0 10400 0.00 D 2016-02-01 Common Stock 10400 104800 D Transaction made pursuant to Dr. Boger's company approved trading plan under Rule 10b5-1. Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $128.96 (range $128.71 to $129.52). Open market sales reported on this line occurred at a weighted average price of $130.25 (range $129.93 to $130.83). Open market sales reported on this line occurred at a weighted average price of $131.55 (range $130.94 to $131.89). Open market sales reported on this line occurred at a weighted average price of $132.44 (range $131.95 to $132.89). Open market sales reported on this line occurred at a weighted average price of $133.03 (range $132.96 to $133.07). Fully vested. Omar White, Attorney-In-Fact 2015-11-20