X0306 4 2015-11-02 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001190290 ULLIAN ELAINE C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2015-11-02 4 M 0 20000 53.85 A 25265 D Common Stock 2015-11-02 4 S 0 900 123.66 D 24365 D Common Stock 2015-11-02 4 S 0 700 125.09 D 23665 D Common Stock 2015-11-02 4 S 0 9592 125.98 D 14073 D Common Stock 2015-11-02 4 S 0 6708 126.91 D 7365 D Common Stock 2015-11-02 4 S 0 2100 127.62 D 5265 D Stock Option (right to buy) 53.85 2015-11-02 4 M 0 20000 0.00 D 2021-05-31 Common Stock 20000 0 D Transaction made pursuant to Ms. Ullian's company approved trading plan under Rule 10b5-1. Ms. Ullian undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $123.66 (range $123.40 to $124.27). Open market sales reported on this line occurred at a weighted average price of $125.09 (range $124.44 to $125.38). Open market sales reported on this line occurred at a weighted average price of $125.98 (range $125.44 to $126.43). Open market sales reported on this line occurred at a weighted average price of $126.91 (range $126.44 to $127.43). Open market sales reported on this line occurred at a weighted average price of $127.62 (range $127.46 to $127.85). Fully vested. Omar White, Attorney-In-Fact 2015-11-04