X0306 4 2015-05-04 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001446372 Silva Paul M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 SVP & Corp Controller Common Stock 2015-05-04 4 M 0 1125 37.86 A 19500 D Common Stock 2015-05-04 4 S 0 577 126.15 D 18923 D Common Stock 2015-05-04 4 S 0 332 127.09 D 18591 D Common Stock 2015-05-04 4 S 0 216 128.22 D 18375 D Common Stock 2015-05-05 4 M 0 1687 45.11 A 20062 D Common Stock 2015-05-05 4 M 0 1289 77.31 A 21351 D Common Stock 2015-05-05 4 S 0 1676 121.92 D 19675 D Common Stock 2015-05-05 4 S 0 1000 122.90 D 18675 D Common Stock 2015-05-05 4 S 0 200 123.85 D 18475 D Common Stock 2015-05-05 4 S 0 100 125.20 D 18375 D Common Stock 169 I 401(k) Stock Option (right to buy) 37.86 2015-05-04 4 M 0 1125 0.00 D 2022-02-01 Common Stock 1125 3375 D Stock Option (right to buy) 45.11 2015-05-05 4 M 0 1687 0.00 D 2023-02-04 Common Stock 1687 11813 D Stock Option (right to buy) 77.31 2015-05-05 4 M 0 1289 0.00 D 2024-02-04 Common Stock 1289 14179 D Transaction made pursuant to Mr. Silva's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $126.15 (range $125.64 to $126.63). Mr. Silva undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $127.09 (range $126.87 to $127.40). Open market sales reported on this line occurred at a weighted average price of $128.22 (range $127.99 to $128.68). Open market sales reported on this line occurred at a weighted average price of $121.92 (range $121.56 to $122.41). Open market sales reported on this line occurred at a weighted average price of $122.90 (range $122.58 to $123.33). Open market sales reported on this line occurred at a weighted average price of $123.85 (range $123.68 to $124.01). The option vests in 16 quarterly installments from 02/02/2012. The option vests in 16 quarterly installments from 02/05/2013. The option vests in 16 quarterly installments from 02/05/2014. Omar White, Attorney-In-Fact 2015-05-06