X0306 4 2015-03-25 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197023 BOGER JOSHUA S C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2015-03-25 4 M 0 1300 17.16 A 387584 D Common Stock 2015-03-25 4 M 0 10400 35.64 A 397984 D Common Stock 2015-03-25 4 S 0 2100 119.03 D 395884 D Common Stock 2015-03-25 4 S 0 3900 119.88 D 391984 D Common Stock 2015-03-25 4 S 0 2600 120.91 D 389384 D Common Stock 2015-03-25 4 S 0 1900 122.68 D 387484 D Common Stock 2015-03-25 4 S 0 1200 123.27 D 386284 D Common Stock 13286 I 401(k) Common Stock 122700 I Common Stock held in trust Stock Option (right to buy) 17.16 2015-03-25 4 M 0 1300 0.00 D 2015-07-19 Common Stock 1300 21300 D Stock Option (right to buy) 35.64 2015-03-25 4 M 0 10400 0.00 D 2016-02-01 Common Stock 10400 458400 D Transaction made pursuant to Dr. Boger's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $119.03 (range $118.50 to $119.49). Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $119.88 (range $119.53 to $120.50). Open market sales reported on this line occurred at a weighted average price of $120.91 (range $120.53 to $121.43). Open market sales reported on this line occurred at a weighted average price of $122.68 (range $122.08 to $123.07). Open market sales reported on this line occurred at a weighted average price of $123.27 (range $123.10 to $123.59). Common stock held in grantor retained annuity trusts. Fully vested. Omar White, Attorney-In-Fact 2015-03-27