X0306 4 2014-12-10 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 1 0 0 CEO & President Common Stock 2014-12-10 4 A 0 125000 0.01 A 270194 D Common Stock 440 I 401(k) Performance-based retention award that will vest if performance objectives are achieved prior to November 15, 2019. The award will vest on December 10, 2017 if the Company achieves positive EBITDA for the 12-month period ending September 30, 2017. Between January 1, 2018 and November 15, 2019, if the Company achieves positive EBITDA for a 12-month period ending on a calendar quarter, the award will vest on the day following the applicable earnings release. Kenneth L. Horton, Attorney-In-Fact 2014-12-12