X0306 4 2014-09-30 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001554979 Pace Megan E C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 0 1 0 0 SVP, Corp. Communications Common Stock 2014-09-30 4 M 0 1172 38.80 A 24522 D Common Stock 2014-09-30 4 M 0 5625 51.75 A 30147 D Common Stock 2014-09-30 4 M 0 3532 37.86 A 33679 D Common Stock 2014-09-30 4 M 0 15250 48.74 A 48929 D Common Stock 2014-09-30 4 M 0 17157 45.11 A 66086 D Common Stock 2014-09-30 4 M 0 6875 83.36 A 72961 D Common Stock 2014-09-30 4 M 0 6875 77.31 A 79836 D Common Stock 2014-09-30 4 S 0 7576 111.32 D 72260 D Common Stock 2014-09-30 4 S 0 21881 112.21 D 50379 D Common Stock 2014-09-30 4 S 0 15400 113.08 D 34979 D Common Stock 2014-09-30 4 S 0 11629 113.90 D 23350 D Stock Option (right to buy) 38.80 2014-09-30 4 M 0 1172 0.00 D 2021-02-02 Common Stock 1172 2344 D Stock Option (right to buy) 51.75 2014-09-30 4 M 0 5625 0.00 D 2021-07-12 Common Stock 5625 1875 D Stock Option (right to buy) 37.86 2014-09-30 4 M 0 3532 0.00 D 2022-02-01 Common Stock 3532 4218 D Stock Option (right to buy) 48.74 2014-09-30 4 M 0 15250 0.00 D 2022-07-24 Common Stock 15250 15250 D Stock Option (right to buy) 45.11 2014-09-30 4 M 0 17157 0.00 D 2023-02-04 Common Stock 17157 28593 D Stock Option (right to buy) 83.36 2014-09-30 4 M 0 6875 0.00 D 2023-07-29 Common Stock 6875 20625 D Stock Option (right to buy) 77.31 2014-09-30 4 M 0 6875 0.00 D 2024-02-04 Common Stock 6875 48125 D Transaction made pursuant to Ms. Pace's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $111.32 (range $110.61 to $111.60). Ms. Pace undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $112.21 (range $111.61 to $112.60). Open market sales reported on this line occurred at a weighted average price of $113.08 (range $112.61 to $113.59). Open market sales reported on this line occurred at a weighted average price of $113.90 (range $113.62 to $114.32). The option vests in 16 quarterly installments from 02/03/2011. The option vests in 16 quarterly installments from 07/13/2011. The option vests in 16 quarterly installments from 02/02/2012. The option vests in 16 quarterly installments from 07/25/2012. The option vests in 16 quarterly installments from 02/05/2013. The option vests in 16 quarterly installments from 07/30/2013. The option vests in 16 quarterly installments from 02/05/2014. Kenneth L. Horton, Attorney-In-Fact 2014-10-01