X0306 4 2014-09-24 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197023 BOGER JOSHUA S C/O VERTEX PHARMACEUTICALS INCORPORATED 50 NORTHERN AVENUE BOSTON MA 02210 1 0 0 0 Common Stock 2014-09-24 4 M 0 5200 11.27 A 344095 D Common Stock 2014-09-24 4 S 0 600 106.25 D 343495 D Common Stock 2014-09-24 4 S 0 1200 107.39 D 342295 D Common Stock 2014-09-24 4 S 0 500 108.57 D 341795 D Common Stock 2014-09-24 4 S 0 100 109.04 D 341695 D Common Stock 2014-09-24 4 S 0 1000 109.71 D 340695 D Common Stock 2014-09-24 4 S 0 1000 111.04 D 339695 D Common Stock 2014-09-24 4 S 0 800 111.69 D 338895 D Common Stock 13286 I 401(k) Common Stock 300000 I Common Stock held in trust Stock Option (right to buy) 11.27 2014-09-24 4 M 0 5200 0.00 D 2014-10-06 Common Stock 5200 5700 D Transaction made pursuant to Dr. Boger's company approved trading plan under Rule 10b5-1. Dr. Boger undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $106.25 (range $105.87 to $106.57). Open market sales reported on this line occurred at a weighted average price of $107.39 (range $106.94 to $107.90). Open market sales reported on this line occurred at a weighted average price of $108.57 (range $108.04 to $109.01). Open market sales reported on this line occurred at a weighted average price of $109.71 (range $109.15 to $110.04). Open market sales reported on this line occurred at a weighted average price of $111.04 (range $110.33 to $111.23). Open market sales reported on this line occurred at a weighted average price of $111.69 (range $111.40 to $111.93). Common stock held in grantor retained annuity trusts. Fully vested. Kenneth L. Horton, Attorney-In-Fact 2014-09-26