X0306 4 2013-11-20 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197036 SACHS BRUCE I C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST. CAMBRIDGE MA 02139 1 0 0 0 Common Stock 2013-11-20 4 S 0 700 63.10 D 62410 D Common Stock 2013-11-20 4 S 0 800 64.21 D 61610 D Common Stock 2013-11-20 4 S 0 4900 65.35 D 56710 D Common Stock 2013-11-20 4 S 0 1700 66.25 D 55010 D Common Stock 2013-11-20 4 S 0 200 67.15 D 54810 D Transaction made pursuant to Mr. Sachs' company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $63.10 (range $62.80 to $63.33). Mr. Sachs undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $64.21 (range $63.82 to $64.62). Open market sales reported on this line occurred at a weighted average price of $65.35 (range $64.92 to $65.86). Open market sales reported on this line occurred at a weighted average price of $66.25 (range $66.00 to $66.80). Open market sales reported on this line occurred at a weighted average price of $67.15 (range $67.14 to $67.16). Kenneth L. Horton, Attorney-In-Fact 2013-11-21