X0306 4 2013-07-25 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001446372 Silva Paul M C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST. CAMBRIDGE MA 02139 0 1 0 0 SVP & Corp Controller Common Stock 2013-07-25 4 M 0 1125 48.74 A 12875 D Common Stock 2013-07-25 4 S 0 100 84.38 D 12775 D Common Stock 2013-07-25 4 S 0 542 86.17 D 12233 D Common Stock 2013-07-25 4 S 0 483 87.29 D 11750 D Common Stock 169 I 401(k) Stock Option 48.74 2013-07-25 4 M 0 1125 0.00 D 2022-07-24 Common Stock 1125 13500 D Transaction made pursuant to Mr. Silva's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $86.17 (range $85.74 to $86.61). Mr. Silva undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $87.29 (range $87.16 to $87.38). The option vests in 16 quarterly installments from 07/25/2012. Kenneth L. Horton, Attorney-In-Fact 2013-07-29