X0306 4 2013-04-29 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001502917 Stamoulis Christiana C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST. CAMBRIDGE MA 02139 0 1 0 0 SVP, Corp Strategy & Bus Devlp Common Stock 2013-04-29 4 M 0 65624 34.57 A 111336 D Common Stock 2013-04-29 4 M 0 12375 33.82 A 123711 D Common Stock 2013-04-29 4 S 0 25302 79.08 D 98409 D Common Stock 2013-04-29 4 S 0 57697 79.69 D 40712 D Common Stock 2013-04-30 4 M 0 1 34.57 A 40713 D Common Stock 2013-04-30 4 S 0 1 77.88 D 40712 D Common Stock 797 I 401(k) Stock Option (right to buy) 34.57 2013-04-29 4 M 0 65624 0.00 D 2019-10-04 Common Stock 65624 9376 D Stock Option (right to buy) 33.82 2013-04-29 4 M 0 12375 0.00 D 2020-07-13 Common Stock 12375 5625 D Stock Option (right to buy) 34.57 2013-04-30 4 M 0 1 0.00 D 2019-10-04 Common Stock 1 9375 D Transaction made pursuant to Ms. Stamoulis's company approved trading plan under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $79.08 (range $78.36 to $79.34). Ms. Stamoulis undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $79.69 (range $79.35 to $80.29). Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 10/05/2009. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/14/2010. Kenneth L. Horton, Attorney-In-Fact 2013-05-01