X0306 4 2013-04-19 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001446372 Silva Paul M C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST. CAMBRIDGE MA 02139 0 1 0 0 SVP & Corp Controller Common Stock 2013-04-19 4 M 0 235 32.16 A 11985 D Common Stock 2013-04-19 4 M 0 2813 33.55 A 14798 D Common Stock 2013-04-19 4 M 0 1875 33.28 A 16673 D Common Stock 2013-04-19 4 M 0 2813 39.05 A 19486 D Common Stock 2013-04-19 4 M 0 1875 33.82 A 21361 D Common Stock 2013-04-19 4 M 0 2813 38.80 A 24174 D Common Stock 2013-04-19 4 M 0 4500 51.75 A 28674 D Common Stock 2013-04-19 4 M 0 3375 37.86 A 32049 D Common Stock 2013-04-19 4 M 0 2250 48.74 A 34299 D Common Stock 2013-04-19 4 S 0 22549 81.50 D 11750 D Common Stock 143 I 401(k) Employee Stock Option (right to buy) 32.16 2013-04-19 4 M 0 235 0.00 D 2018-07-23 Common Stock 235 0 D Employee Stock Option (right to buy) 33.55 2013-04-19 4 M 0 2813 0.00 D 2019-02-04 Common Stock 2813 0 D Employee Stock Option (right to buy) 33.28 2013-04-19 4 M 0 1875 0.00 D 2019-07-15 Common Stock 1875 469 D Employee Stock Option (right to buy) 39.05 2013-04-19 4 M 0 2813 0.00 D 2020-02-03 Common Stock 2813 3750 D Employee Stock Option (right to buy) 33.82 2013-04-19 4 M 0 1875 0.00 D 2020-07-13 Common Stock 1875 2344 D Employee Stock Option (right to buy) 38.80 2013-04-19 4 M 0 2813 0.00 D 2021-02-02 Common Stock 2813 7500 D Employee Stock Option (right to buy) 51.75 2013-04-19 4 M 0 4500 0.00 D 2021-07-12 Common Stock 4500 10125 D Employee Stock Option (right to buy) 37.86 2013-04-19 4 M 0 3375 0.00 D 2022-02-01 Common Stock 3375 13500 D Employee Stock Option (right to buy) 48.74 2013-04-19 4 M 0 2250 0.00 D 2022-07-24 Common Stock 2250 15750 D Transaction made pursuant to Mr. Silva's company approved trading plan under Rule 10b5-1. Fully vested. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/16/2009. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 02/04/2010. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/14/2010. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 02/03/2011. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/13/2011. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 02/02/2012. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 07/25/2012. Kenneth L. Horton, Attorney-In-Fact 2013-04-23