X0305 4 2012-05-09 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001446372 Silva Paul M C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST CAMBRIDGE MA 02139 0 1 0 0 SVP & Corp Controller Common Stock 2012-05-09 4 M 0 7500 36.27 A 13625 D Common Stock 2012-05-09 4 M 0 7032 18.93 A 20657 D Common Stock 2012-05-09 4 M 0 5156 33.28 A 25813 D Common Stock 2012-05-09 4 M 0 3515 32.16 A 29328 D Common Stock 2012-05-09 4 M 0 1125 37.86 A 30453 D Common Stock 2012-05-09 4 M 0 8437 39.05 A 38890 D Common Stock 2012-05-09 4 M 0 4687 38.80 A 43577 D Common Stock 2012-05-09 4 M 0 3281 33.82 A 46858 D Common Stock 2012-05-09 4 M 0 12187 33.55 A 59045 D Common Stock 2012-05-09 4 M 0 3375 51.75 A 62420 D Common Stock 2012-05-09 4 S 0 55295 60.85 D 7125 D Common Stock 2012-05-09 4 S 0 1000 61.08 D 6125 D Common Stock 1380 I 401(k) Stock Option 36.27 2012-05-09 4 M 0 7500 0.00 D 2007-11-13 2017-08-12 Common Stock 7500 0 D Stock Option 18.93 2012-05-09 4 M 0 7032 0.00 D 2008-05-07 2018-02-06 Common Stock 7032 0 D Stock Option 33.28 2012-05-09 4 M 0 5156 0.00 D 2009-10-16 2019-07-15 Common Stock 5156 2344 D Stock Option 32.16 2012-05-09 4 M 0 3515 0.00 D 2008-10-24 2018-07-23 Common Stock 3515 235 D Stock Option 37.86 2012-05-09 4 M 0 1125 0.00 D 2012-05-02 2022-02-01 Common Stock 1125 16875 D Stock Option 39.05 2012-05-09 4 M 0 8437 0.00 D 2010-05-04 2020-02-03 Common Stock 8437 6563 D Stock Option 38.80 2012-05-09 4 M 0 4687 0.00 D 2011-05-03 2021-02-02 Common Stock 4687 10313 D Stock Option 33.82 2012-05-09 4 M 0 3281 0.00 D 2010-10-14 2020-07-13 Common Stock 3281 4219 D Stock Option 33.55 2012-05-09 4 M 0 12187 0.00 D 2009-05-05 2019-02-04 Common Stock 12187 2813 D Stock Option 51.75 2012-05-09 4 M 0 3375 0.00 D 2011-10-13 2021-07-12 Common Stock 3375 14625 D Open market sales reported on this line occurred at a weighted average price of $60.85 (range $60.85 to $60.95). Mr. Silva undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Open market sales reported on this line occurred at a weighted average price of $61.08 (range $61.02 to $61.09). David T. Howton, Attorney-In-Fact 2012-05-16