X0305 4 2012-05-07 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001294596 Wysenski Nancy C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST CAMBRIDGE MA 02139 0 1 0 0 EVP, Chief Commercial Officer Common Stock 2012-05-07 4 M 0 6797 33.82 A 43191 D Common Stock 2012-05-07 4 M 0 12500 39.70 A 55691 D Common Stock 2012-05-07 4 M 0 120000 39.70 A 175691 D Common Stock 2012-05-07 4 M 0 3398 38.80 A 179089 D Common Stock 2012-05-07 4 S 0 147695 54.50 D 31394 D Common Stock 2012-05-08 4 M 0 9063 33.82 A 40457 D Common Stock 2012-05-08 4 M 0 10196 38.80 A 50653 D Common Stock 2012-05-08 4 M 0 18750 39.70 A 69403 D Common Stock 2012-05-08 4 S 0 9063 59.19 D 60340 D Common Stock 2012-05-08 4 S 0 10196 62.08 D 50144 D Common Stock 2012-05-08 4 S 0 18750 63.52 D 31394 D Stock Option 33.82 2012-05-07 4 M 0 6797 0.00 D 2010-10-14 2020-07-13 Common Stock 6897 29453 D Stock Option 39.70 2012-05-07 4 M 0 12500 0.00 D 2010-03-09 2019-12-08 Common Stock 12500 87500 D Stock Option 39.70 2012-05-07 4 M 0 120000 0.00 D 2011-05-23 2019-12-08 Common Stock 120000 180000 D Stock Option 38.80 2012-05-07 4 M 0 3398 0.00 D 2011-05-03 2021-02-02 Common Stock 3398 50977 D Stock Option 33.82 2012-05-08 4 M 0 9063 0.00 D 2010-10-14 2020-07-13 Common Stock 9063 20390 D Stock Option 38.80 2012-05-08 4 M 0 10196 0.00 D 2011-05-03 2021-02-02 Common Stock 10196 40781 D Stock Option 39.70 2012-05-08 4 M 0 18750 0.00 D 2010-03-09 2019-12-08 Common Stock 18750 68750 D Transaction made pursuant to Ms. Wysenski's company approved trading plan under Rule 10b5-1. David T. Howton, Attorney-In-Fact 2011-05-09