X0304 4 2011-12-14 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001242825 LEIDEN JEFFREY M C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST CAMBRIDGE MA 02139 1 1 0 0 CEO Designate Common Stock 2011-12-14 4 A 0 50017 0.01 A 52617 D Common Stock 2011-12-14 4 A 0 133378 0.01 A 185995 D Stock Option 29.99 2011-12-14 4 A 0 458108 0.00 A 2012-03-14 2021-12-13 Common Stock 458108 458108 D Stock grant under 2006 Stock and Option Plan vesting on December 14, 2014. Performance-based stock grant under 2006 Stock and Option Plan that will vest only if Vertex meets certain performance objectives. Up to 50% of the grant will vest on the date of the Company's first regularly scheduled board meeting in 2013 and up to 50% of the grant will vest on the date of the Company's 2014 Annual Meeting of its shareholders. Right to buy under 2006 Stock and Option Plan, vesting in 16 quarterly installments from 12/14/2011. David T. Howton, Attorney-In-Fact 2011-12-16