X0304 4 2011-09-01 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001529297 Howton David T C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY ST CAMBRIDGE MA 02139 0 1 0 0 SVP Common Stock 2011-09-01 4 S 0 328 44.29 D 9271 D Common Stock 264 I 401(k) Transaction made pursuant to Mr. Howton's company approved trading plan under Rule 10b5-1. David T. Howton 2011-09-07