Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (299)	$ (382)	$ (549)	$ (536)
Total stock-based compensation expense included in costs and expenses	31,379	31,879	59,067	59,758
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	22,683	23,903	40,905	43,527
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	152,789		152,789
Weighted-average Recognition Period (in years)			2.78
Restricted stock and restricted stock units
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	7,253	6,835	14,539	13,665
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	53,914		53,914
Weighted-average Recognition Period (in years)			2.59
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	1,742	1,523	4,172	3,102
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	2,298		2,298
Weighted-average Recognition Period (in years)			0.51
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	19,777	20,453	36,981	39,002
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 11,602	$ 11,426	$ 22,086	$ 20,756