Quarterly Financial Data (unaudited) (Tables)

12 Months Ended

Dec. 31, 2011

Quarterly Financial Data (unaudited)

Schedule of Quarterly Financial Data

	Three Months Ended
	March 31, 2011			June 30, 2011			Sept. 30, 2011			Dec. 31, 2011
	(in thousands, except per share amounts)
Revenues:
Product revenues, net	$	—		$	74,535		$	419,595		$	456,759
Royalty revenues		6,061			10,010			8,539			25,405
Collaborative revenues		67,601			29,879			231,066			81,176
Total revenues		73,662			114,424			659,200			563,340
Costs and expenses:
Cost of product revenues		—			5,404			35,285			22,936
Royalty expenses		2,666			3,902			3,121			7,191
Research and development expenses		158,612			173,604			189,052			186,438
Sales, general and administrative expenses		71,523			96,663			110,654			121,881
Restructuring expense (credit)		760			741			(419	)		992
Intangible asset impairment charge		—			—			105,800			—
Total costs and expenses		233,561			280,314			443,493			339,438
Income (loss) from operations		(159,899	)		(165,890	)		215,707			223,902
Interest income		1,402			202			77			197
Interest expense		(12,001	)		(6,962	)		(7,059	)		(12,430	)
Change in fair value of derivative instruments		(5,598	)		(2,220	)		(8,115	)		(868	)
Income (loss) before provision for (benefit from) income taxes		(176,096	)		(174,870	)		200,610			210,801
Provision for (benefit from) income taxes		—			24,448			(27,842	)		22,660
Net income (loss)		(176,096	)		(199,318	)		228,452			188,141
Net income (loss) attributable to noncontrolling interest (Alios)		—			(25,249	)		7,342			29,512
Net income (loss) attributable to Vertex	$	(176,096	)	$	(174,069	)	$	221,110		$	158,629
Net income (loss) per share attributable to Vertex common shareholders:
Basic	$	(0.87	)	$	(0.85	)	$	1.06		$	0.76
Diluted	$	(0.87	)	$	(0.85	)	$	1.02		$	0.74
Shares used in per share calculations:
Basic		202,329			204,413			206,002			206,758
Diluted		202,329			204,413			219,349			217,602

	Three Months Ended
	March 31, 2010			June 30, 2010			Sept. 30, 2010			Dec. 31, 2010
	(in thousands, except per share amounts)
Revenues:
Royalty revenues	$	6,407		$	7,262		$	8,173		$	8,402
Collaborative revenues		16,022			24,360			15,622			57,122
Total revenues		22,429			31,622			23,795			65,524
Costs and expenses:
Royalty expenses		3,367			3,086			3,228			3,049
Research and development expenses		143,012			155,082			170,434			168,888
Sales, general and administrative expenses		35,552			40,915			48,855			62,478
Restructuring expense (credit)		780			2,112			866			(2,257	)
Total costs and expenses		182,711			201,195			223,383			232,158
Loss from operations		(160,282	)		(169,573	)		(199,588	)		(166,634	)
Interest income		455			484			493			523
Interest expense		(3,955	)		(3,683	)		(3,951	)		(7,686	)
Change in fair value of derivative instruments		(1,489	)		(27,234	)		(5,911	)		(6,595	)
Net loss attributable to Vertex	$	(165,271	)	$	(200,006	)	$	(208,957	)	$	(180,392	)
Basic and diluted net loss per share attributable to Vertex common shareholders	$	(0.83	)	$	(1.00	)	$	(1.04	)	$	(0.90	)
Basic and diluted weighted-average number of common shares outstanding		198,935			200,397			200,887			201,355