Stock-based Compensation Expense - Schedule of Stock-based Compensation Expense by Line Item (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Stock-based compensation expense:
Stock-based compensation expense	$ 685.9	$ 698.5	$ 581.2
Stock-based compensation expense related to inventories	(14.4)	(10.6)	(2.3)
Total stock-based compensation expense included in “Total costs and expenses”	685.9	698.5	581.2
Income tax effect	(128.6)	(251.6)	(167.5)
Total stock-based compensation expense, net of tax	557.3	446.9	413.7
Cost of sales
Stock-based compensation expense:
Stock-based compensation expense	11.1	7.5	7.5
Research and development expenses
Stock-based compensation expense:
Stock-based compensation expense	415.4	425.8	354.9
Selling, general and administrative expenses
Stock-based compensation expense:
Stock-based compensation expense	259.4	265.2	218.8
Restricted stock units (including PSUs)
Stock-based compensation expense:
Stock-based compensation expense	672.1	689.1	563.7
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense	27.0	18.2	15.8
Stock options
Stock-based compensation expense:
Stock-based compensation expense	$ 1.2	$ 1.8	$ 4.0