Condensed Consolidated Statements of Income (Loss) - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2025	Sep. 30, 2024	Sep. 30, 2025	Sep. 30, 2024
Total revenues	$ 3,076.4	$ 2,771.9	$ 8,811.3	$ 8,108.1
Costs and expenses:
Cost of sales	414.8	392.6	1,185.3	1,107.1
Research and development expenses	977.7	875.9	2,935.8	2,631.6
Acquired in-process research and development expenses	54.5	15.0	76.5	4,540.9
Selling, general and administrative expenses	445.1	371.8	1,266.1	1,086.7
Intangible asset impairment charge	0.0	0.0	379.0	0.0
Change in fair value of contingent consideration	(1.9)	0.3	1.2	0.7
Total costs and expenses	1,890.2	1,655.6	5,843.9	9,367.0
Income (loss) from operations	1,186.2	1,116.3	2,967.4	(1,258.9)
Interest income	125.7	132.2	369.0	469.9
Interest expense	(3.3)	(7.5)	(10.0)	(27.8)
Other expense, net	(9.8)	(16.9)	(14.2)	(71.2)
Income (loss) before provision for income taxes	1,298.8	1,224.1	3,312.2	(888.0)
Provision for income taxes	215.9	178.7	550.1	560.6
Net income (loss)	$ 1,082.9	$ 1,045.4	$ 2,762.1	$ (1,448.6)
Net income (loss) per common share:
Basic (in dollars per share)	$ 4.24	$ 4.05	$ 10.77	$ (5.61)
Diluted (in dollars per share)	$ 4.20	$ 4.01	$ 10.68	$ (5.61)
Shares used in per share calculations:
Basic (in shares)	255.6	258.0	256.4	258.1
Diluted (in shares)	257.6	261.0	258.6	258.1
Product revenues, net
Total revenues	$ 3,076.4	$ 2,771.9	$ 8,780.6	$ 8,108.1
Other revenues
Total revenues	$ 0.0	$ 0.0	$ 30.7	$ 0.0