Segment Information - Additional Information (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Disaggregation of Revenue [Line Items]
Product revenues	$ 2,964,700,000	$ 2,645,600,000	$ 5,734,900,000	$ 5,336,200,000
Depreciation and amortization expense	51,700,000	54,000,000.0	100,100,000	107,500,000
CASGEVY
Disaggregation of Revenue [Line Items]
Product revenues	30,400,000	0	44,600,000	0
JOURNAVX
Disaggregation of Revenue [Line Items]
Product revenues	$ 12,000,000.0	$ 0	$ 13,300,000	$ 0