Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Jun. 30, 2025	Jun. 30, 2024
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 167.3	$ 154.2	$ 333.4	$ 346.1
Stock-based compensation expense related to inventories	(3.9)	(2.8)	(6.8)	(3.9)
Total stock-based compensation expense included in “Total costs and expenses”	167.3	154.2	333.4	346.1
Income tax effect	(36.5)	(80.7)	(111.7)	(159.7)
Total stock-based compensation expense, net of tax	130.8	73.5	221.7	186.4
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	2.5	1.8	5.1	3.6
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	99.6	97.1	199.7	216.5
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	65.2	55.3	128.6	126.0
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	162.9	150.7	326.3	337.9
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	7.1	4.5	12.7	10.3
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 1.2	$ 1.8	$ 1.2	$ 1.8