Segment Information - Schedule of Revenues by Product (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2025	Mar. 31, 2024
Revenue from External Customer [Line Items]
Total product revenues, net	$ 2,770.2	$ 2,690.6
Product revenues, net
Revenue from External Customer [Line Items]
Total product revenues, net	2,760.2	2,690.6
TRIKAFTA/KAFTRIO
Revenue from External Customer [Line Items]
Total product revenues, net	2,535.5	2,483.6
ALYFTREK
Revenue from External Customer [Line Items]
Total product revenues, net	53.9	0.0
Other product revenues
Revenue from External Customer [Line Items]
Total product revenues, net	$ 170.8	$ 207.0