Stock-based Compensation Expense - Schedule of Stock-based Compensation Expense by Line Item (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Stock-based compensation expense:
Stock-based compensation expense	$ 698.5	$ 581.2	$ 491.3
Stock-based compensation expense related to inventories	(10.6)	(2.3)	0.9
Total stock-based compensation expense included in “Total costs and expenses”	698.5	581.2	491.3
Income tax effect	(251.6)	(167.5)	(144.1)
Total stock-based compensation expense, net of tax	446.9	413.7	347.2
Cost of sales
Stock-based compensation expense:
Stock-based compensation expense	7.5	7.5	9.4
Research and development expenses
Stock-based compensation expense:
Stock-based compensation expense	425.8	354.9	297.9
Selling, general and administrative expenses
Stock-based compensation expense:
Stock-based compensation expense	265.2	218.8	184.0
Restricted stock units (including PSUs)
Stock-based compensation expense:
Stock-based compensation expense	689.1	563.7	456.1
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense	18.2	15.8	16.7
Stock options
Stock-based compensation expense:
Stock-based compensation expense	$ 1.8	$ 4.0	$ 17.6