Consolidated Statements of Income - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Statement [Abstract]
Product revenues, net	$ 11,020.1	$ 9,869.2	$ 8,930.7
Costs and expenses:
Cost of sales	1,530.5	1,262.2	1,080.3
Research and development expenses	3,630.3	3,162.9	2,540.3
Acquired in-process research and development expenses	4,628.4	527.1	115.5
Selling, general and administrative expenses	1,464.3	1,136.6	944.7
Change in fair value of contingent consideration	(0.5)	(51.6)	(57.5)
Total costs and expenses	11,253.0	6,037.2	4,623.3
(Loss) income from operations	(232.9)	3,832.0	4,307.4
Interest income	598.1	614.7	144.6
Interest expense	(30.6)	(44.1)	(54.8)
Other income (expense), net	(86.1)	(22.8)	(164.8)
Income before provision for income taxes	248.5	4,379.8	4,232.4
Provision for income taxes	784.1	760.2	910.4
Net (loss) income	$ (535.6)	$ 3,619.6	$ 3,322.0
Net (loss) income per common share:
Basic (in dollars per share)	$ (2.08)	$ 14.05	$ 12.97
Diluted (in dollars per share)	$ (2.08)	$ 13.89	$ 12.82
Shares used in per share calculations:
Basic (in shares)	257.9	257.7	256.1
Diluted (in shares)	257.9	260.5	259.1