Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Variable Rate [Domain] Variable Rate [Domain] Pay vs Performance Disclosure [Line Items] Accrued expenses Accrued Liabilities, Current Other long-term liabilities Other Noncurrent Liabilities [Member] Statistical Measurement [Domain] Statistical Measurement [Domain] Line of credit facility, maximum borrowing capacity Line of Credit Facility, Maximum Borrowing Capacity Research and development expenses Research and Development Expense Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Debt covenant, consolidated leverage ratio Debt Covenant, Consolidated Leverage Ratio Consolidated leverage ratio that must be maintained in order to be in compliance with debt covenants. Award Type [Domain] Award Type [Domain] Ourania Tatsis [Member] Ourania Tatsis Fair Value as of Grant Date Award Grant Date Fair Value Acquired in-process research and development expenses Research and Development Asset Acquired Other than Through Business Combination, Writeoff Other current liabilities Other Current Liabilities [Member] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Investments, Debt and Equity Securities [Abstract] Investments, Debt and Equity Securities [Abstract] Revolving Credit Facility Revolving Credit Facility [Member] Schedule of Cash Equivalents and Marketable Securities Cash, Cash Equivalents and Investments [Table Text Block] Effect of changes in exchange rates on cash Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] Accounts payable Accounts Payable, Current Prepaid expenses and other current assets Prepaid Expenses and Other Current Assets [Member] Restatement Determination Date: Restatement Determination Date [Axis] Corporate debt securities Corporate Debt Securities [Member] Commitments and contingencies Commitments and Contingencies Insider Trading Policies and Procedures [Line Items] Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Derivative asset current, foreign currency forward contracts Derivative Asset, Current Disaggregation of Revenue [Line Items] Disaggregation of Revenue [Line Items] Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Line of Credit Facility [Line Items] Line of Credit Facility [Line Items] Geographical [Axis] Geographical [Axis] Income Taxes Income Tax Disclosure [Text Block] Canadian dollar Canada, Dollars Total financial liabilities Financial Liabilities Fair Value Disclosure Current liabilities: Liabilities, Current [Abstract] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding Preferred Stock, Value, Issued Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Derivative Instruments, Gain (Loss) [Line Items] Derivative Instruments, Gain (Loss) [Line Items] Diluted (in dollars per share) Diluted net income per common share (in dollars per share) Earnings Per Share, Diluted Total liabilities Gross Amounts Recognized Derivative Liability, Subject to Master Netting Arrangement, before Offset Net unrealized gains (losses) Unrealized Gain (Loss) on Investments PEO Total Compensation Amount PEO Total Compensation Amount Hedging Relationship [Axis] Hedging Relationship [Axis] Accounts receivable, net Accounts Receivable, after Allowance for Credit Loss, Current Collaborative Arrangements by Agreement [Domain] Collaborative Arrangements by Agreement [Domain] Collaborative Arrangements by Agreement [Domain] Unrealized (losses) gains on foreign currency forward contracts, net of tax of $4.2, $(16.1), $11.6 and $(18.3), respectively Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification and Tax, Parent Trading Arrangements, by Individual Trading Arrangements, by Individual [Table] Level 3 Fair Value, Inputs, Level 3 [Member] Sangeeta Bhatia [Member] Sangeeta Bhatia Trading Symbol Trading Symbol Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Interest income Investment Income, Interest and Dividend Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Unrealized holding losses on marketable securities, tax OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment, Tax Net income Net income Net income Net income Net Income (Loss) Total current liabilities Liabilities, Current Derivative Contract [Domain] Derivative Contract [Domain] Schedule of Cash Flow Hedging Instruments Schedule of Notional Amounts of Outstanding Derivative Positions [Table Text Block] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Company Selected Measure Name Company Selected Measure Name All Currencies [Domain] All Currencies [Domain] Property and equipment, net Property, Plant, and Equipment and Finance Lease Right-of-Use Asset, after Accumulated Depreciation and Amortization Liabilities and Shareholders’ Equity Liabilities and Equity [Abstract] ESPP share issuances Employee Stock [Member] Repurchase of common stock Value of shares repurchased Stock Repurchased During Period, Value Derivative Instruments, Gain (Loss) [Table] Derivative Instruments, Gain (Loss) [Table] Amounts reclassified from accumulated other comprehensive income (loss) Reclassification from AOCI, Current Period, Net of Tax, Attributable to Parent Unrealized loss Gross Unrealized Losses Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax Contract liabilities Contract with Customer, Liability Schedule of Earnings Per Share, Basic and Diluted Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Cost of sales Cost of Goods and Services Sold Executive Category: Executive Category [Axis] Level 1 Fair Value, Inputs, Level 1 [Member] Name Measure Name Marketable securities Marketable Securities, Current Name Forgone Recovery, Individual Name British pound sterling United Kingdom, Pounds Goodwill Goodwill Equity Components [Axis] Equity Components [Axis] Equity Components [Axis] Financial Instruments [Domain] Financial Instruments [Domain] Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Hedging Relationship [Domain] Hedging Relationship [Domain] Certificates of deposit Certificates of Deposit [Member] Asset Acquisition [Domain] Asset Acquisition [Domain] Underlying Securities Award Underlying Securities Amount Entity Small Business Entity Small Business Accumulated Other Comprehensive Income (Loss) Comprehensive Income (Loss) Note [Text Block] Local Phone Number Local Phone Number Accounts receivable, net Increase (Decrease) in Accounts Receivable Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Letters of Credit Letter of Credit [Member] Forecast Forecast [Member] Selling, general and administrative expenses Selling, General and Administrative Expenses [Member] Notional amount of foreign currency forward contract Derivative, Notional Amount Fair Value by Measurement Frequency [Axis] Measurement Frequency [Axis] Long-term operating lease liabilities Operating Lease, Liability, Noncurrent Restricted stock units (including PSUs) Unvested restricted stock units (including PSUs) Restricted Stock Units (RSUs) [Member] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Purchase of common stock Payment To Acquire Common Stock Payment To Acquire Common Stock Schedule of Foreign Exchange Contracts Schedule of Foreign Exchange Contracts, Statement of Financial Position [Table Text Block] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Reclassification out of Accumulated Other Comprehensive Income [Axis] Reclassification out of Accumulated Other Comprehensive Income [Axis] Line of Credit Facility [Table] Line of Credit Facility [Table] Income Statement Location [Axis] Income Statement Location [Axis] Research and development expenses Research and Development Expense (Excluding Acquired in Process Cost) Issuance of common stock under benefit plans (in shares) Stock Issued During Period, Shares, Employee Benefit Plan Total stock-based compensation expense, net of tax Share-Based Payment Arrangement, Expense, after Tax Common stock withheld for employee tax obligations Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation Foreign currency forward contracts Foreign Exchange Forward [Member] Europe Europe [Member] SYMDEKO/SYMKEVI SYMDEKO/SYMKEVI [Member] SYMDEKO/SYMKEVI [Member] Product and Service [Domain] Product and Service [Domain] Schedule of Potential Gross Common Equivalent Shares Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Other Performance Measure, Amount Other Performance Measure, Amount Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Inventories Increase (Decrease) in Inventories Unrealized holding losses on marketable securities, net of tax of $4.3, zero, $3.5 and zero, respectively Other Comprehensive Income (Loss), Available-for-Sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Research and development expenses Research and Development Expense [Member] Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Carmen Bozic [Member] Carmen Bozic Antidilutive securities excluded from computation of earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Award Type [Axis] Award Type [Axis] Derivative Instruments and Hedging Activities Disclosure [Abstract] Derivative Instruments and Hedging Activities Disclosure [Abstract] Unrealized gains (losses) on foreign currency forward contracts, tax Other Comprehensive Income (Loss), Cash Flow Hedge, Gain (Loss), after Reclassification, Tax, Parent Document Quarterly Report Document Quarterly Report Fair Value, Measurements, Fair Value Hierarchy [Domain] Fair Value Hierarchy and NAV [Domain] Additional Cash Flow Information Additional Financial Information Disclosure [Text Block] Hedging Designation [Axis] Hedging Designation [Axis] Trading Arrangement: Trading Arrangement [Axis] Contingent consideration, measurement input (as a percent) Business Combination, Contingent Consideration, Liability, Measurement Input Publicly Traded Companies Sale Publicly Traded Companies Sale [Member] Publicly Traded Companies Sale Use of Estimates Use of Estimates, Policy [Policy Text Block] PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Corporate equity securities Equity Securities, FV-NI and without Readily Determinable Fair Value [Abstract] Schedule of Provision for (Benefits from) Income Taxes and Effective Tax rates Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Stock-based compensation expense: Share-based Compensation Allocation [Abstract] -- None. No documentation exists for this element. -- Total marketable debt securities Debt Securities, Available-for-Sale [Abstract] Entity File Number Entity File Number Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Amortized Cost Cash Equivalents And Debt Securities, Available for Sale Cash Equivalents And Debt Securities, Available for Sale Offsetting Derivative Liabilities [Abstract] Offsetting Derivative Liabilities [Abstract] Discount Rate Measurement Input, Discount Rate [Member] Derivative term Derivative, Term of Contract On Available-For-Sale Debt Securities AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-Sale, Parent [Member] Allowance for credit loss for available-for-sale debt securities Debt Securities, Available-for-Sale, Allowance for Credit Loss Entity Shell Company Entity Shell Company Other comprehensive income (loss) before reclassifications OCI, before Reclassifications, Net of Tax, Attributable to Parent Restatement Determination Date Restatement Determination Date Schedule of Offsetting Liabilities Offsetting Liabilities [Table Text Block] KALYDECO KALYDECO [Member] KALYDECO inventories, net Other liabilities Increase (Decrease) in Other Operating Liabilities Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash, cash equivalents and restricted cash—beginning of period Cash, cash equivalents and restricted cash—end of period Cash, cash equivalents and restricted cash per condensed consolidated statement of cash flows Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Government-sponsored enterprise securities Government-sponsored enterprise securities US Government-sponsored Enterprises Debt Securities [Member] Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] ORKAMBI ORKAMBI [Member] ORKAMBI [Member] Unrealized loss position for greater than twelve months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Common stock, shares issued (in shares) Common Stock, Shares, Issued Schedule of Company's Net Unrealized Gains (Losses) on Corporate Equity Securities Unrealized Gain (Loss) on Investments [Table Text Block] Security Exchange Name Security Exchange Name Total financial assets Assets, Fair Value Disclosure Selling, general and administrative expenses Selling, General and Administrative Expense Accumulated other comprehensive (loss) income Accumulated Other Comprehensive Income (Loss), Net of Tax Swiss Franc Switzerland, Francs Acquired In-Process Research and Development and Other Arrangements Collaborative Arrangement Disclosure [Text Block] Foreign Currency Translation Adjustment Foreign Currency Forward Contract Accumulated Foreign Currency Adjustment Attributable to Parent [Member] Stock options Stock options Employee Stock Option [Member] Hedging Derivative Instruments and Hedging Activities Disclosure [Text Block] CRISPR T1D CRISPR T1D [Member] CRISPR T1D Gross Amounts Not Offset Derivative Liability, Subject to Master Netting Arrangement, Deduction of Financial Instrument Not Offset Legal Offset Derivative Liability, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Collaborative arrangement, development and regulatory potential milestone payments maximum Collaborative Arrangement Development And Regulatory Potential Milestone Payments Maximum Represents the potential milestone amount to be paid by the entity under the collaboration agreement if drug candidates are approved and commercialized. Total costs and expenses Costs and Expenses Other financing activities Proceeds from (Payments for) Other Financing Activities Maximum Maximum [Member] Comprehensive income Comprehensive Income (Loss), Net of Tax, Attributable to Parent Document Type Document Type Tabular List, Table Tabular List [Table Text Block] Entity Address, Address Line One Entity Address, Address Line One Long-term marketable securities Marketable Securities, Noncurrent Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Other current liabilities, foreign currency forward contracts Derivative Liability, Current Stock-based Compensation Expense and Share Repurchase Programs Share-Based Payment Arrangement [Text Block] Up-front payment Collaborative Arrangement Up-front License Fee Collaborative Arrangement Up-front License Fee Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Other non-cash items, net Other Noncash Income (Expense) Purchases of available-for-sale debt securities Payments to Acquire Debt Securities, Available-for-Sale Gross Unrealized Losses Equity Securities, FV-NI, Unrealized Loss Derivative [Table] Derivative [Table] Other current liabilities Other Liabilities, Current Variable Rate [Axis] Variable Rate [Axis] Income Statement [Abstract] Income Statement [Abstract] Raw materials Inventory, Raw Materials, Net of Reserves Costs and expenses: Costs and Expenses [Abstract] Title of 12(b) Security Title of 12(b) Security Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Cash equivalents: Cash and Cash Equivalents, Fair Value Disclosure Gross Amounts Presented Derivative Liability Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Amortized Cost Debt and Equity Securities, Cost Debt and Equity Securities, Cost Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Collaborative Arrangements by Agreement [Axis] Collaborative Arrangements by Agreement [Axis] Significant terms of collaboration arrangements, by individual agreement. Share-based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Entity Tax Identification Number Entity Tax Identification Number Inventories Total Inventory, Net Stock-based compensation expense related to inventories Share-Based Payment Arrangement, Amount Capitalized Statistical Measurement [Axis] Statistical Measurement [Axis] Balance Sheet Location [Domain] Balance Sheet Location [Domain] Financial Instrument [Axis] Financial Instrument [Axis] Entity Interactive Data Current Entity Interactive Data Current Disaggregation of Revenue [Table] Disaggregation of Revenue [Table] Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-Sale [Table] Adjustments to reconcile net income to net cash provided by operating activities: Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Total Shareholder Return Amount Total Shareholder Return Amount Repurchases of common stock Payments for Repurchase of Common Stock Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Other Assets Other assets Other Assets [Member] Share-based Compensation Arrangement by Share-based Payment Award Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Retained earnings Retained Earnings (Accumulated Deficit) Measure: Measure [Axis] Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Name Outstanding Recovery, Individual Name Gross Amounts Not Offset Derivative Asset, Subject to Master Netting Arrangement, Deduction of Financial Instrument Not Offset Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Current assets: Assets, Current [Abstract] Entity Address, State or Province Entity Address, State or Province Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Antidilutive Securities Excluded from Computation of Earnings Per Share Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Common stock, shares outstanding (in shares) Beginning balance (in shares) Ending balance (in shares) Common Stock, Shares, Outstanding Maturities of available-for-sale debt securities Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale PEO PEO [Member] Accumulated Other Comprehensive Income (Loss) [Line Items] Accumulated Other Comprehensive Income (Loss) [Line Items] Total assets Gross Amounts Recognized Derivative Asset, Subject to Master Netting Arrangement, before Offset Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Remaining milestone payment Business Combination, Remaining Milestone Payment Business Combination, Remaining Milestone Payment Net cash used in investing activities Net Cash Provided by (Used in) Investing Activities Fair Value Equity Securities, FV-NI, Current Schedule of Inventories by Type Schedule of Inventory, Current [Table Text Block] Schedule of Foreign Exchange Contracts, Condensed Consolidated Statements of Operations Reclassification out of Accumulated Other Comprehensive Income [Table Text Block] Other long-term liabilities, foreign currency forward contracts Derivative Liability, Noncurrent Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Effective tax rate Effective Income Tax Rate Reconciliation, Percent Terrence Kearney [Member] Terrence Kearney Measurement Input Type [Domain] Measurement Input Type [Domain] Milestone payment Collaborative Arrangement, Milestone Payment Collaborative Arrangement, Milestone Payment Credit Facility [Axis] Credit Facility [Axis] Total liabilities Liabilities Asset Acquisition [Axis] Asset Acquisition [Axis] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Accumulated Other Comprehensive Income (Loss) Total AOCI Attributable to Parent [Member] Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Debt securities fair value, unrealized loss position Debt Securities, Available-for-Sale, Unrealized Loss Position Measurement Frequency [Domain] Measurement Frequency [Domain] All Executive Categories All Executive Categories [Member] Accumulated Other Comprehensive Income (Loss) [Table] Accumulated Other Comprehensive Income (Loss) [Table] Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Income tax effect Share-Based Payment Arrangement, Expense, Tax Benefit Net income per common share: Earnings Per Share [Abstract] Common stock, $0.01 par value; 500,000,000 shares authorized, 257,792,648 and 257,011,628 shares issued and outstanding, respectively Common Stock, Value, Issued Matures after one year through five years Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, after Year One Through Five Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Deferred income taxes Increase (Decrease) in Other Deferred Liability Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Total current assets Assets, Current Fair Value Cash Equivalents And Debt Securities, Available for Sale, Fair Value Disclosure Cash Equivalents And Debt Securities, Available for Sale, Fair Value Disclosure Payments on finance leases Finance Lease, Principal Payments Beginning balance Ending balance Business Combination, Contingent Consideration, Liability Corporate equity securities Equity Securities [Member] Revenue from Contract with Customer [Abstract] Revenue from Contract with Customer [Abstract] All Individuals All Individuals [Member] Supplemental disclosure of cash flow information: Supplemental Cash Flow Information [Abstract] Other income (expense), net Other income (expense), net Other Nonoperating Income (Expense) Entity Filer Category Entity Filer Category Non-PEO NEO Average Total Compensation Amount Non-PEO NEO Average Total Compensation Amount Statement [Table] Statement [Table] Contingent consideration Business Combination, Contingent Consideration, Liability, Noncurrent Current Fiscal Year End Date Current Fiscal Year End Date Number of shares authorized to be repurchased Stock Repurchase Program, Authorized Amount Repurchase of common stock (in shares) Shares repurchased (in shares) Stock Repurchased During Period, Shares Contingent liabilities Contingent Liabilities Contingent Liabilities Marketable Securities and Equity Investments Cash, Cash Equivalents, and Marketable Securities [Text Block] PEO Name PEO Name Entrada Therapeutics Entrada Therapeutics [Member] Entrada Therapeutics Schedule of Accumulated Other Comprehensive Income (Loss) Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block] Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Base Rate Base Rate [Member] Issuance of common stock under benefit plans Stock Issued During Period, Value, Employee Benefit Plan Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Asset-backed securities Asset-Backed Securities [Member] Net cash provided by operating activities Net Cash Provided by (Used in) Operating Activities Other current liabilities, contingent consideration Business Combination, Contingent Consideration, Liability, Current Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] CRISPR JDCA CRSIPR JDCA [Member] CRISPR Amended and restated the Original CTX001 JDCA Depreciation expense Depreciation, Depletion and Amortization Euro Euro Member Countries, Euro Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Total shareholders’ equity Beginning balance Ending balance Equity, Attributable to Parent Indemnification claims Indemnification Claims Amount of indemnification claims currently outstanding Commercial paper Commercial Paper [Member] Net unrecognized tax benefits which would affect the tax rate if recognized Unrecognized Tax Benefits that Would Impact Effective Tax Rate Restricted stock units (including PSUs) Restricted Stock [Member] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Prepaid expenses and other current assets Restricted Cash and Cash Equivalents Debt covenant, increase in consolidated leverage ratio Debt Covenant, Increase In Consolidated Leverage Ratio Debt Covenant, Increase In Consolidated Leverage Ratio Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Table] Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Table] Schedule of the cash and cash equivalents and available-for-sale investments held by the entity. Catalyst Biosciences Catalyst Biosciences [Member] Catalyst Biosciences On Foreign Currency Forward Contracts Accumulated Gain (Loss), Net, Cash Flow Hedge, Parent [Member] Long-term marketable securities Marketable Securities, Noncurrent [Member] Marketable Securities, Noncurrent Income before provision for income taxes Income before provision for income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Schedule of Additional Cash Flow Information Condensed Cash Flow Statement [Table Text Block] Equity securities without readily determinable fair value, amount Equity Securities without Readily Determinable Fair Value, Amount Not Designated as Hedging Instrument Not designated as hedging instruments Not Designated as Hedging Instrument [Member] Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Hedging Designation [Domain] Hedging Designation [Domain] Level 2 Fair Value, Inputs, Level 2 [Member] Entity Emerging Growth Company Entity Emerging Growth Company Investment in equity securities and notes receivable Payments to Acquire Equity Securities, FV-NI Intangible assets Intangible Assets, Net (Excluding Goodwill) Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Named Executive Officers, Footnote Named Executive Officers, Footnote [Text Block] Document Fiscal Period Focus Document Fiscal Period Focus Accrued expenses Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Title Trading Arrangement, Individual Title Stock-based compensation expense Share-Based Payment Arrangement, Noncash Expense Common Stock Common Stock [Member] Individual: Individual [Axis] City Area Code City Area Code Entity Address, Postal Zip Code Entity Address, Postal Zip Code Product and Service [Axis] Product and Service [Axis] Earnings Per Share Earnings Per Share [Text Block] Income Statement Location [Domain] Income Statement Location [Domain] Other assets, foreign currency forward contracts Derivative Asset, Noncurrent Document Fiscal Year Focus Document Fiscal Year Focus Geographical [Domain] Geographical [Domain] Minimum Minimum [Member] Shares used in per share calculations: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Basis of Presentation and Accounting Policies Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block] Exercise Price Award Exercise Price Cash Cash CRISPR CRISPR [Member] CRISPR Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Assets Assets [Abstract] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Payments in connection with common stock withheld for employee tax obligations Payment, Tax Withholding, Share-Based Payment Arrangement U.S. Treasury securities US Treasury Securities [Member] Cash paid for income taxes Income Taxes Paid, Net Net cash used in financing activities Net Cash Provided by (Used in) Financing Activities Deferred tax assets Deferred Income Tax Assets, Net Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Retained Earnings Retained Earnings [Member] Summary of cash, cash equivalents and marketable securities Schedule of Cash, Cash Equivalents and Available-for-sale Securities [Line Items] -- None. No documentation exists for this element. -- Schedule of Stock-based Compensation Expense by Line Item Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Total liabilities and shareholders’ equity Liabilities and Equity Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Other assets Other Assets, Noncurrent Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Operating lease assets Operating Lease, Right-of-Use Asset Basic (in dollars per share) Basic net income per common share (in dollars per share) Earnings Per Share, Basic Accounting Policies [Abstract] Accounting Policies [Abstract] Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Currency [Axis] Currency [Axis] Arrangement Duration Trading Arrangement Duration Entity Address, City or Town Entity Address, City or Town Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Total marketable debt securities Marketable Securities And Other Noncurrent Assets [Member] Marketable Securities And Other Noncurrent Assets Schedule of Fair Value of Our Contingent Consideration Liabilities Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table Text Block] Document Transition Report Document Transition Report Award Timing Predetermined Award Timing Predetermined [Flag] SOFR Loan Secured Overnight Financing Rate (SOFR) [Member] Secured Overnight Financing Rate (SOFR) Stock repurchase program, remaining amount Stock Repurchase Program, Remaining Authorized Repurchase Amount Termination Date Trading Arrangement Termination Date Proceeds received Proceeds from Sale and Maturity of Marketable Securities Accounts payable Increase (Decrease) in Accounts Payable Common stock, shares authorized (in shares) Common Stock, Shares Authorized Fair Value Debt securities Total Debt Securities, Available-for-Sale Gross Unrealized Gains Equity Securities, FV-NI, Unrealized Gain Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] CRISPR Therapeutics CRISPR Therapeutics AG [Member] CRISPR Therapeutics AG Derivative Instrument [Axis] Derivative Instrument [Axis] Allocation of net profits and net losses, percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Collaborative Arrangement, Allocation Of Net Profits And Losses, Percent Gross Unrealized Gains Debt and Equity Securities, Unrealized Gain Debt and Equity Securities, Unrealized Gain All Trading Arrangements All Trading Arrangements [Member] Measurement Input Type [Axis] Measurement Input Type [Axis] All Adjustments to Compensation All Adjustments to Compensation [Member] Derivative [Line Items] Derivative [Line Items] Award Timing Disclosures [Line Items] Compensation Amount Outstanding Recovery Compensation Amount Marketable securities Marketable Securities [Member] Marketable Securities [Member] Gross Amounts Presented Derivative Asset Comprehensive Income (Loss), Net of Tax, Including Portion Attributable to Noncontrolling Interest [Abstract] Statement of Comprehensive Income [Abstract] Australian dollar Australia, Dollars TRIKAFTA/KAFTRIO TRIKAFTA/KAFTRIO [Member] TRIKAFTA/KAFTRIO [Member] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Insider Trading Arrangements [Line Items] AOCI Attributable to Parent, Net of Tax [Roll Forward] AOCI Attributable to Parent, Net of Tax [Roll Forward] Entity Registrant Name Entity Registrant Name Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Award Timing Method Award Timing Method [Text Block] Share-based payment arrangements (in shares) Incremental Common Shares Attributable to Dilutive Effect of Share-Based Payment Arrangements (Gains) losses on equity securities Equity Securities, FV-NI, Unrealized Gain (Loss) Adjustment to Compensation, Amount Adjustment to Compensation Amount Cost of sales Cost of Sales [Member] Change in fair value of contingent consideration Decrease in fair value of contingent consideration Decrease in fair value of contingent payments Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Document Period End Date Document Period End Date Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Adoption Date Trading Arrangement Adoption Date Amit Sachdev [Member] Amit Sachdev Schedule of Financial Assets Subject to Fair Value Measurements Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Long-term finance lease liabilities Finance Lease, Liability, Noncurrent Entity Central Index Key Entity Central Index Key Reclassification out of Accumulated Other Comprehensive Income Reclassification out of Accumulated Other Comprehensive Income [Member] Financial instruments carried at fair value (liability positions): Liabilities, Fair Value Disclosure [Abstract] Total stock-based compensation expense included in costs and expenses Share-Based Payment Arrangement, Expense Non-Rule 10b5-1 Arrangement Terminated Non-Rule 10b5-1 Arrangement Terminated [Flag] Provision for income taxes Income Tax Expense (Benefit) Finished goods Inventory, Finished Goods, Net of Reserves Total product revenues outside of the United States Non-US [Member] Designated as Hedging Instruments Designated as hedging instruments Designated as Hedging Instrument [Member] Fair Value Measurements Fair Value Disclosures [Text Block] Number of operating segments Number of Operating Segments Name Trading Arrangement, Individual Name Cash equivalents: Cash and Cash Equivalents [Abstract] Total other comprehensive (loss) income Other comprehensive loss, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Schedule of Disaggregation of Revenue Disaggregation of Revenue [Table Text Block] Equity [Abstract] Equity [Abstract] Debt Securities, Available-for-sale [Line Items] Debt Securities, Available-for-Sale [Line Items] Inventories Inventory Disclosure [Text Block] Product revenues, net Revenue from Contract with Customer, Excluding Assessed Tax Entity [Domain] Entity [Domain] Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Amendment Flag Amendment Flag Other Other, Non U.S. [Member] Other, Non U.S. [Member] Legal Entity [Axis] Legal Entity [Axis] Gross Amounts Offset Derivative Liability, Subject to Master Netting Arrangement, Asset Offset Money market funds Money Market Funds [Member] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Common stock withheld for employee tax obligations (in shares) Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Interest expense Interest Income (Expense), Net Matures within one year Debt Securities, Available-for-Sale, Fair Value, Maturity, Allocated and Single Maturity Date, Year One Financial instruments carried at fair value (asset positions): Assets, Fair Value Disclosure [Abstract] Credit Facility [Domain] Credit Facility [Domain] Time deposits Bank Time Deposits [Member] Basis spread on variable rate (as a percent) Debt Instrument, Basis Spread on Variable Rate Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Fair Value Debt and Equity Securities, Fair Value Debt and Equity Securities, Fair Value Diluted (in shares) Diluted weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Diluted Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Revenue Recognition Revenue from Contract with Customer [Text Block] Offsetting Derivative Assets [Abstract] Offsetting Derivative Assets [Abstract] Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Company Selected Measure Amount Company Selected Measure Amount Additional paid-in capital Additional Paid in Capital, Common Stock Legal Offset Derivative Asset, Fair Value, Offset Against Collateral, Net of Not Subject to Master Netting Arrangement, Policy Election Investments with restrictions Restricted Investments, at Fair Value Additional Paid-in Capital Additional Paid-in Capital [Member] Sale of equity securities Proceeds from Sale of Equity Securities, FV-NI Effect of potentially dilutive securities: Weighted Average Number of Shares Outstanding, Diluted, Adjustment [Abstract] Balance Sheet Location [Axis] Balance Sheet Location [Axis] Total assets Assets Name Awards Close in Time to MNPI Disclosures, Individual Name Employee stock purchase program (in shares) Incremental Common Shares Attributable to Dilutive Effect of Equity Unit Purchase Agreements Gross Unrealized Losses Debt and Equity Securities, Unrealized Loss Debt and Equity Securities, Unrealized Loss Cover [Abstract] Cover [Abstract] Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition United States UNITED STATES Recurring Basis Fair Value, Recurring [Member] Other long-term liabilities Other Liabilities, Noncurrent Non-NEOs Non-NEOs [Member] Cash Flow Hedging Cash Flow Hedging [Member] Asset acquisition, consideration transferred Asset Acquisition, Consideration Transferred Net (decrease) increase in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Non-PEO NEO Non-PEO NEO [Member] Marketable securities: Marketable Securities Equity Component [Domain] Equity Component [Domain] Line of credit facility additional borrowing capacity Line Of Credit Facility Additional Borrowing Capacity Amount of increased borrowing capacity available in the future. Adjustment to Compensation: Adjustment to Compensation [Axis] Original cost Amortized Cost Equity Securities, FV-NI, Cost Schedule of Offsetting Assets Offsetting Assets [Table Text Block] Work-in-process Inventory, Work in Process, Net of Reserves Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Gross Amounts Offset Derivative Asset, Subject to Master Netting Arrangement, Liability Offset Scenario [Axis] Scenario [Axis] Basic (in shares) Basic weighted-average common shares outstanding (in shares) Weighted Average Number of Shares Outstanding, Basic Entity Current Reporting Status Entity Current Reporting Status Collaborative arrangement, right to exclusively license, number of targets Collaborative Arrangement, Right To License, Number Of Targets Collaborative Arrangement, Right To License, Number Of Targets David Altshuler [Member] David Altshuler Income from operations Operating Income (Loss) Revenues: Revenues [Abstract] Cash equivalents: Cash and cash equivalents Cash and Cash Equivalents [Member] Issuances of common stock under benefit plans Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Statement Statement [Line Items] Other comprehensive (loss) income: Other Comprehensive Income (Loss), Net of Tax [Abstract] Total stock-based compensation expense included in “Total costs and expenses” Share-Based Payment Arrangement, Expensed and Capitalized, Amount Scenario [Domain] Scenario [Domain] Forgone Recovery due to Disqualification of Tax Benefits, Amount Forgone Recovery due to Disqualification of Tax Benefits, Amount Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Shareholders’ equity: Equity, Including Portion Attributable to Noncontrolling Interest [Abstract] Reclassification out of Accumulated Other Comprehensive Income [Domain] Reclassification out of Accumulated Other Comprehensive Income [Domain]